Folding fluorine-containing pyridine intermediates into hot spots
At present, the quinolone antibiotics that have been developed and put into mass production in China include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin and fleroxacin. Among them, norfloxacin, ciprofloxacin and ofloxacin produced the largest amount, accounting for 98% of the total production of domestic fluoroquinolone antibacterials.
Quinolones are generally obtained by synthesizing a fluorine-containing quinolate compound from a fluorine-containing benzene ring and then condensing it with piperazine (or methyl piperazine). Due to the abundant fluorite reserves in China, it is one of the countries with the largest production of fluorine-containing drugs and intermediates in the world, and more than 80% of fluorine-containing intermediates are exported. On the whole, China's fluorobenzene intermediates developed earlier, and the current production capacity is generally surplus; the development of benzotrifluoride intermediates is relatively late, and the development speed is faster in recent years; for heterocyclic aromatic compounds, especially fluorinated pyridines. Class, China has only a few research units and manufacturers have the synthesis technology of fluorine-containing pyridine intermediates. Therefore, fluorine-containing pyridine intermediates will become one of the main directions for the development of domestic fluorine-containing intermediates in the next few years.