Folic acid, also known as vitamin B9, is a water-soluble vitamin.
The Sino-US cooperation project on preventing neural tube defects was launched in 1990. After Chinese and American scientists tracked and observed 250,000 newly-married women and their pregnancy outcomes , expectant mothers took 0.4 mg of folic acid during pregnancy and developed high incidence of neural tube defects. The district has an 85% prevention rate and a 41% prevention rate in the low-risk area of neural tube defects. This scientific and technological achievement has been widely used and referenced in more than 50 countries around the world. Folic acid is also used to treat anemia in women, but consumers must carefully consider the instructions when choosing to buy, and choose according to different situations.
One of the folic acid vitamin B complexes, equivalent to pteroylglutamic acid (PGA), was extracted and purified from spinach leaves by M. K. Mitchell (1941). Folic acid. It has the effect of promoting the maturation of young cells in the bone marrow. The lack of folic acid in humans can cause macrocytic anemia and leukopenia, which is especially important for pregnant women.
Natural folic acid
Natural folic acid is widely found in animal and plant foods, especially in yeast, liver and green leafy vegetables.
Synthetic folic acid
There are many foods containing folic acid, but because the natural folic acid is extremely unstable, it is easily oxidized by the influence of sunlight and heat, so the body can really get not much folic acid from food. Folic acid bioavailability is low at around 45%. The synthesized folic acid can be kept stable for several months or years, is easy to absorb and has high human utilization, which is about twice as high as that of natural products.
Folic acid is initially extracted from liver leaching solution and produced by synthetic methods. The traditional synthetic route of folic acid is formed by acylation, condensation, reduction and cyclization of nitrobenzoic acid. The process is long, the yield is low, and the production cost is high. The reaction of trimethoxypropanol and p-aminobenzoyl-L-glutamic acid as main raw materials with triaminopyrimidine sulfate produces folic acid with a total yield of 75% and a purity of 98%.