Pharmaceutical Fluoxetine

- Aug 28, 2018 -

Fluoxetine, a widely used selective 5-HT reuptake inhibitor (SSRI), selectively inhibits 5-HT transporters and blocks pre-synaptic membrane reuptake of 5-HT. Prolongs and increases the effects of 5-HT, resulting in an antidepressant effect. The affinity for adrenergic, histamine, and cholinergic receptors is low, and the effect is weak, resulting in fewer adverse reactions. After oral administration, the absorption is good, the bioavailability is 70%, easy to pass the blood-brain barrier, and a small amount can be secreted into the milk. It is metabolized by CYP2D6 in the liver to produce mefoxetine, which also has antidepressant effects.

 

Indication

1Applicable to depression and its accompanying anxiety, especially for senile depression.

2 for the treatment of obsessive-compulsive disorder, but the drug dose should be increased accordingly.

3 applies to bulimia nervosa.

4 for the treatment of panic state, also has a certain effect on generalized anxiety disorder.